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Effect of substances of polypeptide nature isolated from the cerebral cortex on the immune response in mice

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of low-molecular-weight polypeptides (mol. wt.<10,000) isolated by acetic acid extraction from bovine cerebral cortex and white matter and red bone marrow on the primary immune response to sheep's red blood cells was investigated in experiments on 248 male CBA mice. Subcutaneous injection of the preparation from the cortex (where the θ-antigen cross-reacting with thymocytes is located) into the animals for the 5 days before and 3 days after immunization led to an increase of 2.5 times in the hemagglutinin titer and in the number of direct (IgM) and indirect (IgG) antibody-forming cells compared with the control. Preparations from the white matter of the brain and red bone marrow had no such effect.

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Authors
  1. G. A. Belokrylov
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  2. V. G. Morozov
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  3. V. Kh. Khavinson
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Belokrylov, G.A., Morozov, V.G. & Khavinson, V.K. Effect of substances of polypeptide nature isolated from the cerebral cortex on the immune response in mice. Bull Exp Biol Med 86, 1631–1633 (1978). https://doi.org/10.1007/BF00801823

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  • DOI: https://doi.org/10.1007/BF00801823

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