Bulletin of Experimental Biology and Medicine

, Volume 86, Issue 6, pp 1565–1568 | Cite as

Effect of acetylcholine on discharge frequency and shape of action potentials of pacemaker cells

  • G. I. Bochkina
  • G. S. Sukhova
  • M. G. Udel'nov


The action of exogenous acetylcholine on the isolated pacemaker of the frog heart was studied. Activity of single cells and the total activity of the preparation were recorded. Exogenous acetylcholine had not only an inhibitory, but also an accelerating effect on the rhythm of discharge of the pacemaker cells. As a rule an accelerating action was observed when relatively low concentrations of acetylcholine were used. An increase in the rate of rise of slow diastolic depolarization during the development of parasympathetic acceleration is evidence of the active mechanism of this process. The difference in the effects of acetylcholine was probably due to differences in the action of large and small concentrations of the drug on transmembrane ionic currents.

Key Words

acetylcholine pacemaker cells acceleration of rhythm inhibition of rhythm 


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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • G. I. Bochkina
  • G. S. Sukhova
  • M. G. Udel'nov

There are no affiliations available

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