Bulletin of Experimental Biology and Medicine

, Volume 87, Issue 3, pp 211–214 | Cite as

Binding of prostaglandins E by plasma membranes of thyroid cells

  • V. D. Malinkovich
  • V. Yu. Gal'chinskaya
Biochemistry and Biophysics
  • 18 Downloads

Abstract

The ability of the plasma membranes of human and bovine thyrocytes to bind prostaglandins of the E group (PGE) was investigated by the use of material from kits for the radioimmunological determination of PGE. Sites for specific binding of PGE with high and low affinity constants for prostaglandins were found to exist on the plasma membranes of human and bovine thyrocytes. Binding of PGE by the membrane is under the influence of thyrotrophin and cyclic nucleotides.

Key Words

prostaglandins plasma membrane thyroid gland cyclic nucleotides 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    V. D. Malinkovich, Dokl. Akad. Nauk Ukr. SSR, Ser. B., Geol. Khim. Biol. Nauki, No. 5, 446 (1977).Google Scholar
  2. 2.
    P. F. Rokitskii, Biological Statistics [in Russian], Minsk (1973), p. 141.Google Scholar
  3. 3.
    M. F. Abdel-Wahab, M. S. Abdo, A. A. Farahat, et al., Endokrinologie (Berlin),64, 323 (1975).Google Scholar
  4. 4.
    G. Burke, J. Lab. Clin. Med.,74, 856 (1969).Google Scholar
  5. 5.
    G. Burke, Endocrinology,94, 91 (1974).Google Scholar
  6. 6.
    S. Madaoui, J. Rappoport, and J. Nunes, Biochimie,56, 109 (1974).Google Scholar
  7. 7.
    A. Melander, F. Sundler, and S. J. Ingbar, Endocrinology,92, 1269 (1974).Google Scholar
  8. 8.
    W. V. Moore and J. Wolff, J. Biol. Chem.,248, 570 (1973).Google Scholar
  9. 9.
    G. Scatchard, Ann. N. Y. Acad. Sci.,51, 660 (1949).Google Scholar
  10. 10.
    J. Wolff and A. B. Jones, J. Biol. Chem.,246, 3439 (1971).Google Scholar
  11. 11.
    S.-C. Yu, L. Chand, and G. Burke, J. Clin. Invest.,51, 1114 (1972).Google Scholar
  12. 12.
    U. Zor. T. Koneko, T. Lowe, et al., J. Biol. Chem.,244, 5189 (1969).Google Scholar

Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • V. D. Malinkovich
  • V. Yu. Gal'chinskaya

There are no affiliations available

Personalised recommendations