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Effect of psychotropic drugs on orienting and investigative behavior after fright induced by acoustic stimulation

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

After frightening acoustic stimulation a state of alertness and anxiety arises and leads to weakening of attention to the new situation and intensification of the orienting reaction toward the source of sound. Defensive motivation arising under these conditions does not change with an increase in loudness of the sound. The tranquilizers diazepam (Seduxen), benactyzine, and chlordiazepoxide (Librium), the antidepressants amitriptuline and imipramine, and the neuroleptics trifluoperazine and haloperidol, in small doses, prevent these disturbances. Pentobarbital, chlorpromazine, and also trifluoperazine and haloperidol in large doses, do not prevent these consequences of emotional excitation.

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Salimov, R.M. Effect of psychotropic drugs on orienting and investigative behavior after fright induced by acoustic stimulation. Bull Exp Biol Med 84, 1603–1606 (1977). https://doi.org/10.1007/BF00801691

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  • DOI: https://doi.org/10.1007/BF00801691

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