Abstract
In poisoning caused by injection ofClostridiumperfringens type A toxin or a mixture of toxin with the filtrate of a culture ofClostridium butyricum, changes in the microcirculation in the mucous membrane of the retrobuccal pouch of golden hamsters were found. The microcirculatory changes took place in two phases. In the first phase vasomotor disturbances were observed, as shown by periodic changes in diameter of the arterial microvessels, and by plasmatization and a decrease in the number of functioning capillaries. The diameter of the veins showed no significant change. The second phase was characterized by persistent disturbances of the microcirculation: slowing of the blood flow in the arterial and venous portions, the appearance of regions of stasis, a retrograde blood flow, and arterial dilatation. The persistent disturbances of the microcirculation following injection of a mixture ofCl. perfringens toxin and filtrate of a broth culture ofCl. butyricum appeared sooner than those in response to injection of the toxin alone.
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Tselukh, A.V., Donskikh, E.A., Shtefan, É.É. et al. Changes in the microcirculation during the combined action of clostridium perfringens type a toxin and metabolic products of clostridium butyricum. Bull Exp Biol Med 84, 1571–1573 (1977). https://doi.org/10.1007/BF00801679
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DOI: https://doi.org/10.1007/BF00801679