Abstract
The intensity of incorporation of [5-3H]uridine into the nucleus and cytoplasm of fibroblasts during wound healing in control mice and in mice receiving potassium orotate and the intensity of incorporation of [3H]proline into the same cells and into the intercellular spaces between them were studied. Incorporation of [3H]proline was shown to take place much more intensively than that of [5-3H]uridine. A considerable increase was observed in RNA synthesis in the fibroblasts under the influence of potassium orotate, accompanied by a less marked increase in synthesis of proline-containing proteins under analogous conditions. The dynamics of the nucleo-cytoplasmic ratios revealed by autoradiographic investigation correlated with the ultrastructural changes in the fibroblasts in the course of their differentiation.
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Dudnikova, G.N. Autoradiographic analysis of the effect of potassium orotate on the intensity of [5-3H]uridine and [3H]proline into wound fibroblasts. Bull Exp Biol Med 87, 653–655 (1979). https://doi.org/10.1007/BF00801414
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DOI: https://doi.org/10.1007/BF00801414