Abstract
During regeneration of the mouse liver after poisoning with CCl4 and paracetamol, hepatocytes containing α-fetoprotein (αFP) lose their membrane antigen that served as marker for biliary capilaries. Both during regeneration and in early postnatal development, cessation of αFP synthesis by the cells coincides with the appearance of an antigen marking the biliary capillaries on their surface. It is suggested that cessation of αFP synthesis is the result of establishment of a system of contacts characteristic of the definitive hepatic column.
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Gleiberman, A.S., Khramkova, N.I. & Beloshapkina, T.D. Structure of the liver as a possible factor in the regulation of α-fetoprotein synthesis. Bull Exp Biol Med 87, 607–610 (1979). https://doi.org/10.1007/BF00801399
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DOI: https://doi.org/10.1007/BF00801399