Hematopoietic tissue reactions associated with growth of syngeneic transplantable tumors in mice

Abstract

Growth of a hemangiopericytoma in syngeneic (CBA×C57BL/6j)F₁ male mice led to regular changes in hematopoiesis: an increase in the weight and number of the spleen cells, an increase in the number of colony-forming units (CFU) in the spleen, intensification of myelopoiesis in the spleen, and the development of leukocytosis with a sharp increase in the number of polymorphonuclear granulocytes in the circulating blood, i.e., a “leukemoid reaction” syndrome. This syndrome developed also when tumor cells were injected into a splenectomized host. A leukemoid reaction, although less marked, also was found in the late stages of development of a hepatoma, transplanted into syngeneic (CBA×C57BL/6j)F₁ male mice. Meanwhile, transplantation of a syngeneic strain of carcinoma of the bladder into the same mice did not lead to the development of a leukemoid reaction.