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Expression of type C oncornavirus proteins in tumors of CC57BR mice

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Expression of the genome of endogenous type C oncornaviruses of mice in tumors induced by methylcholanthrene (MC) in mice of strain CC57BR, with a low incidence of leukemia, was studied by radioimmunodiffusion with precipitating test systems. The gs-1 antigen of p30 protein of type C murine viruses and the type-specific antigen of Gross virus (AGLV) were used as markers of the virus genome. Primary and transplantable sarcomas induced by MC were found to contain the gs-1 antigen, whereas AGLV appears only during passage of the tumors. Clear correlation was found between the quantity of p30 protein (titer of the gs-1 antigen) and the presence of AGLV: the gs-1 titer increased considerably simultaneously with the appearance of AGLV and disappearance of AGLV was always accompanied by a fall in the gs-1 titer. The results are evidence of coordinated expression of the two test proteins of endogenous type C murine oncornaviruses in chemically induced tumors of CC57BR mice.

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Authors
  1. B. P. Bogovskii
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  2. O. M. Lezhneva
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Bogovskii, B.P., Lezhneva, O.M. Expression of type C oncornavirus proteins in tumors of CC57BR mice. Bull Exp Biol Med 85, 359–361 (1978). https://doi.org/10.1007/BF00801358

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  • DOI: https://doi.org/10.1007/BF00801358

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