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Physicochemical properties of microbial antigens and immunoallergic tests

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experiments were carried out on guinea pigs with the delayed or immediate type of allergic sensitization. Different antigens, obtained fromBrucella abortus strain 19-VA were used for the sensitizing and reacting injections. The reacting properties of the corpuscular and soluble (sonicated) antigens and of purified protein (P) and polysaccharide (PS) fractions and RNA were compared in skin tests of immediate and delayed types, passive cutaneous anaphylaxis (PCA), acute anaphylactic shock (AS) and the Schultz-Dale reaction on the isolated intestine. Delayed and immediate and allergic reactions were produced by whole soluble antigen and the P fraction. Immediate reactions to purified P fraction were weaker than to whole soluble antigen, by which the animals were sensitized. The PS and RNA fractions were inactive in allergic reactions.

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Authors and Affiliations

  1. Academy of Sciences of the Kazakh SSR, USSR

    N. D. Beklemishev

Authors
  1. N. D. Beklemishev
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  2. G. S. Sukhodoeva
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  3. Ya. L. Bul'vakhter
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  4. N. G. Shin
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Additional information

Department of Allergology and Immunology and Department of Brucellosis, Kazakh Research Institute of Epidemiology, Microbiology, and Infectious Diseases, Alma-Ata. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 85, No. 3, pp. 322–325, March, 1978.

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Beklemishev, N.D., Sukhodoeva, G.S., Bul'vakhter, Y.L. et al. Physicochemical properties of microbial antigens and immunoallergic tests. Bull Exp Biol Med 85, 344–347 (1978). https://doi.org/10.1007/BF00801354

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  • DOI: https://doi.org/10.1007/BF00801354

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