Abstract
γ-Globulin isolated from rabbit sera containing antibodies against denatured DNA or cytidine reduces the efficiency of colony formation in agarized cultures of human bone marrow. Antibodies against DNA isolated from immune sera by means of an immunoadsorbent possess a similar action. After removal of antibodies against denatured DNA from the sera of intact animals and immune sera, the γ-globulin from these sera in a concentration of 0.28 and 5 mg per 2·105 explanted nucleated cells had no effect on colony formation, but if added in a dose of 15 mg stimulated growth of the colonies.
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Kolesnikova, A.I., Podgorodnichenko, V.K., Poverennyi, A.M. et al. Effect of antibodies against denatured DNA on human bone marrow cells forming colonies in semisolid agar. Bull Exp Biol Med 85, 339–341 (1978). https://doi.org/10.1007/BF00801352
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DOI: https://doi.org/10.1007/BF00801352