Abstract
During overstimulation (electrical stimulation for 3 h) of rats considerable changes are observed in their brain metabolism. These changes are manifested as exhaustion of the noradrenalin reserves and disturbance of energy metabolism, leading to a fall in the creatine phosphate level. Preliminary (before electrical stimulation) administration of ethimizole prevented the noradrenalin and creatine phosphate deficiencies in the brain tissue of the overstimulated animals.
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Moreva, E.V., Bul'on, V.V. Effect of ethimizole on changes in brain metabolism caused by overstimulation. Bull Exp Biol Med 85, 315–317 (1978). https://doi.org/10.1007/BF00801345
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DOI: https://doi.org/10.1007/BF00801345