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Effect of parachlorophenylalanine and 5-hydroxytryptophan on the caudate nucleus in cats

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Parachlorophenylalanine, an inhibitor of serotonin synthesis, raised the thresholds of the contraversive reaction, the arrest reaction, and the spindle waves accompanying it in the sensomotor cortex of unanesthetized, unrestrained cats during stimulation of the rostro-ventral zones of the caudate nucleus. The effects arising from the dorsomedial zones of the head and body of the nucleus changed in opposite directions. The serotonin precursor 5-hydroxytryptophan, on the other hand, potentiated most indices of caudate nuclear activity irrespective of the site of stimulation. The existence of serotoninergic mechanisms in the rostro-ventral zones of the nucleus antagonistic to the dopaminergic system and capable of triggering certain caudate functions is postulated.

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Authors
  1. É. B. Arushanyan
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  2. B. A. Tolpyshev
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Arushanyan, É.B., Tolpyshev, B.A. Effect of parachlorophenylalanine and 5-hydroxytryptophan on the caudate nucleus in cats. Bull Exp Biol Med 85, 311–315 (1978). https://doi.org/10.1007/BF00801344

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  • DOI: https://doi.org/10.1007/BF00801344

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