Abstract
The body temperature and response to pyrogenal were studied in germfree and ordinary mice and miniature piglets. The body temperature of intact germfree mice and miniature piglets was found to be below that of ordinary animals of the same species. After intraperitoneal injection of pyrogenal (10 minimal pyrogenic doses) into mice and intramuscular injection of pyrogenal into piglets (500 minimal pyrogenic doses) the absence of a marked febrile reaction was observed in the germfree animals. The results point to the important role of the autoflora in the development of the ability of the animal to produce a temperature reaction and fever.
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Literature Cited
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Podoprigora, G.I. Body temperature and response to pyrogenal in germfree and ordinary animals. Bull Exp Biol Med 85, 272–273 (1978). https://doi.org/10.1007/BF00801332
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DOI: https://doi.org/10.1007/BF00801332