Abstract
A cytochemical investigation of the state of the lysosomal membranes of the phagocytes and lymphocytes of the blood, trachea, and lungs of rabbits during immunization with adsorbed staphylococcal toxoid and with human serum albumin, during experimental inflammation of the lungs, and during pneumonia following immunization, is described. Changes as a result of immunization (systemic destabilization of the lysosomal membranes of the phagocytes and lymphocytes, microcirculatory disorders and infiltrative changes in the lungs) were shown to be premorbid relative to the pneumonia and to intensify the existing inflammation. It is suggested that these changes are a structural and functional manifestation of immunopathological reactions accompanying inflammation of the lungs.
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Birkun, A.A., Yashchenko, L.V. Cytohistochemical characteristics of immunopathological changes during inflammation of the lungs. Bull Exp Biol Med 86, 954–957 (1978). https://doi.org/10.1007/BF00801323
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DOI: https://doi.org/10.1007/BF00801323