Age-related changes in the content of clonogenic stromal precursor cells in the hematopoietic organs of guinea pigs

  • S. Yu. Sidorovich
  • N. V. Latsinik
Morphology and Pathomorphology


The population of stromal precursors in the femoral marrow, spleen, and thymus was determined by monolayer culture of hematopoietic and lymphoid tissue in guinea pigs of different ages. The number of clonogenic stromal precursor cells was found to depend on the animals' age. It reached a maximum in the femoral marrow and spleen after 2 months, thereafter it remained unchanged with age in the spleen, but decreased significantly in the bone marrow. In the period of active function of the thymus the population of its stromal precursors remained relatively constant, but in old guinea pigs no stromal precursors were present.

Key Words

hematopoietic and lymphopoietic organs monolayer culture stromal precursors age changes 

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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • S. Yu. Sidorovich
  • N. V. Latsinik

There are no affiliations available

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