Effect of preliminary neurosensitization of rats on postnatal development of the cerebral cortex in the progeny

  • G. F. Konokotina
Experimental Biology


The cerebral cortex of young rats aged 30 days born of animals previously neurosensitized with homologous cerebral cortical antigens and of intact animals was investigated. A decrease in the width of the sensomotor area was found compared with the control, mainly on account of the lower layers; the cell bodies of the large neurons were reduced in size in layer V, their cytoplasm was incompletely developed, and the accumulation of basophilic material in the cytoplasm was retarded.

Key Words

preliminary neurosensitization progeny cerebral cortex postnatal development 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    M. Sh. Verbitskii, A. G. Bashlai, et al., Vopr. Okhr. Mat., No. 11, 46 (1971).Google Scholar
  2. 2.
    L. S. Volkova, Immunobiological Relations between Mother and Fetus [in Russian], Moscow (1970).Google Scholar
  3. 3.
    O. E. Vyazov, Vest. Akad. Med. Nauk SSSR, No. 6, 32 (1973).Google Scholar
  4. 4.
    N. T. Zubtsova, in: Fetal and Neonatal Cerebral Pathology [in Russian], Moscow (1972), pp. 13–23.Google Scholar
  5. 5.
    B. N. Klosovskii et al., in: Antinatal Care of the Fetus [in Russian], Moscow (1968), pp. 208–219.Google Scholar
  6. 6.
    M. Ya. Maizelis, S. F. Semenov, and R. D. Kogan, in: Immunology of Nervous and Mental Diseases [in Russian], Moscow (1974), pp. 311–313.Google Scholar
  7. 7.
    Z. D. Pigareva, Biochemistry of the Developing Brain [in Russian], Moscow (1972).Google Scholar
  8. 8.
    K. A. Semenova, N. T. Zubtsova, V. V. Batmanova, et al., in: Immunology of Nervous and Mental Diseases [in Russian], Moscow (1974), pp. 42–47.Google Scholar
  9. 9.
    K. A. Semenova and Z. I. Golubovskaya, Trudy Moskovsk. Nauch.-Issled. Inst. Psikhiat. Min. Zdrav. RSFSR,54, 22 (1968).Google Scholar
  10. 10.
    J. Altman et al., J. Comp. Neurol.,126, 357 (1966).Google Scholar
  11. 11.
    P. Darer, J. Hirnforsch,15, 49 (1974).Google Scholar
  12. 12.
    S. Gluecksohn-Waelsch, J. Embryol. Exp. Morph.,5, 83 (1957).Google Scholar
  13. 13.
    A. C. Sharma et al., Ind. J. Med. Sci.,26, 45 (1972).Google Scholar

Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • G. F. Konokotina

There are no affiliations available

Personalised recommendations