Effect of antihepatocytotoxic serum on DNA synthesis in the rat

  • I. N. Alekseeva
Experimental Biology


Incorporation of thymidine-3H into parenchymatous and reticulo-endothelial cells of the liver was studied autoradiographically in adult female rats treated with small doses (0.06 μg/100 g body weight per injection) of antihepatocytotoxic serum (AHTS), the γ-globulin isolated from it (γAHTS), and the γ-globulin fraction of normal rabbit serum (γNRS) to intact animals and to rats with liver damage caused by carbon tetrachloride (CCl4). Following injection of γAHTS and, to a lesser degree, of AHTS into intact animals the index of labeled nuclei of both the parenchymatous and the reticulo-endothelial cells was increased. When given after preliminary CCl4 administration, γAHTS stimulated reparative regeneration. The action of γAHTS took place in phases: A period of increase in the index of labeled nuclei was followed by a period of decrease, and this again was followed by a fresh period of stimulation of proliferative processes.

Key Words

liver antihepatocytotoxic serum carbon tetrachloride index of labeled nuclei 


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Copyright information

© Plenum Publishing Corporation 1978

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  • I. N. Alekseeva

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