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Effect of cesium, lithium, and rubidium on some actions of morphine

  • V. M. Bulaev
  • R. U. Ostrovskaya
Pharmacology
  • 11 Downloads

Abstract

The effect of cesium, lithium, and rubidium chlorides on the analgesic action of morphine (in the vocalization test) and on the course of dependence on it (by the “two bottle” test) was investigated. The chlorides were shown to reduce both the threshold of the pain response and the duration of analgesia produced by morphine. Cesium chloride was most active in this respect. All the compounds studied reduced the coefficient of morphine preference. The greatest effect was observed with cesium chloride, which reduced the preference coefficient to one-fortieth of the control level.

Key Words

lithium cesium rubidium dependence on morphine 

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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • V. M. Bulaev
  • R. U. Ostrovskaya

There are no affiliations available

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