Effect of cesium, lithium, and rubidium on some actions of morphine

  • V. M. Bulaev
  • R. U. Ostrovskaya


The effect of cesium, lithium, and rubidium chlorides on the analgesic action of morphine (in the vocalization test) and on the course of dependence on it (by the “two bottle” test) was investigated. The chlorides were shown to reduce both the threshold of the pain response and the duration of analgesia produced by morphine. Cesium chloride was most active in this respect. All the compounds studied reduced the coefficient of morphine preference. The greatest effect was observed with cesium chloride, which reduced the preference coefficient to one-fortieth of the control level.

Key Words

lithium cesium rubidium dependence on morphine 


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Literature Cited

  1. 1.
    R. Byck, Lancet,2, 72 (1976).Google Scholar
  2. 2.
    B. Carrol and P. Sharp, Science,172, 1355 (1971).Google Scholar
  3. 3.
    D. Dahlstrom, G. Paalzow, and L. Paalzow, Life Sci.,17, 11 (1975).Google Scholar
  4. 4.
    B. Fernandez and J. Ternes, Bull. Psychonom. Soc.,5, 331 (1975).Google Scholar
  5. 5.
    D. Jasinski, J. Nutt, C. Haertzen, et al., Science,195, 582 (1977).Google Scholar
  6. 6.
    J. Jensen, Acta Pharmacol. (Copenhagen),35, 395 (1974).Google Scholar
  7. 7.
    D. McMillan, F. Waddell, and C. Cathcart, J. Pharmacol. Exp. Ther.,190, 416 (1974).Google Scholar
  8. 8.
    F. Messina and J. Krantz, Am. J. Pharmacol.,145, 17 (1973).Google Scholar
  9. 9.
    G. Paalzow and L. Paalzow, Psychopharmacologia (Berlin),45, 9 (1975).Google Scholar
  10. 10.
    L. Saarnivara and P. Mannisto, Arch. Int. Pharmacodyn.,222, 282 (1976).Google Scholar
  11. 11.
    M. Weischer and K. Opitz, Arzneimittel-Forsch.,20, 1046 (1970).Google Scholar

Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • V. M. Bulaev
  • R. U. Ostrovskaya

There are no affiliations available

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