Distribution of γ-hydroxybutyric acid in different parts of the brain and blood serum during development of anesthesia in rats
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The dynamics of accumulation of γ-hydroxybutyric acid (GHBA) in various parts of the brain (thalamus, hypothalamus, cerebellum, corpus striatum, cerebral hemispheres, medulla, corpora quadrigemina) and in the blood serum of rats was studied by an improved gas-chromatographic method after intraperitoneal injection of sodium γ-hydroxybutyrate (1.5 g/kg). The GHBA concentration in all parts of the brain studied during induction and development of anesthesia and recovery of the animals from it was practically identical, although at all stages of anesthesia a higher level of the compound was found in the cerebral hemispheres, cerebellum, and corpus striatum. The GHBA concentration in the blood serum was constantly higher (especially in the initial period) than in the brain tissues.
Key WordsSodium hydroxybutyrate central nervous system blood gas chromatography
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