Abstract
Ability of osteogenic precursors of bone marrow from intact and induced (by implantation of decalcified bone matrix) bones to support themselves was compared by transplantation in diffusion chambers. Osteogenesis continued for several months in bone marrow transplants from intact bones whereas in transplants from induced bone tissue active osteogenesis, although still observed after 12–20 days, ceased after 2 months. Fibroblasts from the second passage from cultures of hematopoietic tissue of induced bones, unlike fibroblasts from cultures of intact bone marrow, were virtually without osteogenic powers. These results confirm that induced osteogenic tissue has limited ability of self-support after the action of the inducer has ceased, compared with intact bone tissue.
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Lalykina, K.S., Latsinik, N.V., Epikhina, S.Y. et al. Self-support of induced bone tissue. Bull Exp Biol Med 81, 271–273 (1976). https://doi.org/10.1007/BF00801094
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DOI: https://doi.org/10.1007/BF00801094