Abstract
The effect of hypoxic and cytotoxic hypoxia on creatine kinase (CK) activity of the blood plasma, the brain, heart, and liver tissues, and the nuclear and mitochondrial fractions of the brain was studied. Hypoxia causes marked changes in CK activity of all the tissues and organelles studied. The magnitude and direction of the changes in CK activity depend on the type and duration of hypoxia, the organ-specificity of the CK, and disturbance of the permeability of cell membranes.
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Govorova, L.V., Teplov, S.I. Changes in creatine kinase activity in the brain, heart, liver, and blood plasma of hypoxia rats. Bull Exp Biol Med 81, 182–184 (1976). https://doi.org/10.1007/BF00801063
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DOI: https://doi.org/10.1007/BF00801063