Abstract
Activity of lactate, succinate, glucose-6-phosphate, β-hydroxybutyrate, NADH, and NADPH dehydrogenases, and of alkaline and acid phosphatases in the kidneys was investigated in intact cats, during hexobarbital anesthesia, after hypotension produced by injection of a ganglion blocker (Arfonad) for 5 h, 24 h after the end of artificial hypotension, and after massive blood loss. All parts of the nephron responded by differential changes of enzyme activity. A sharp decrease in the role of the principal pathway of oxidation (the Krebs cycle) in energy metabolism took place, and under the conditions of circulatory hypoxia the glycolytic pathway and pentose shunt became predominant.
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Kurilin, A.P. Microspectrophotometric characteristics of renal enzymes in acute circulatory failure. Bull Exp Biol Med 83, 732–735 (1977). https://doi.org/10.1007/BF00800765
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DOI: https://doi.org/10.1007/BF00800765