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Autoradiographic study of DNA synthesis in rats with experimental myocardial infarction

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Tritium-labeled thymidine was injected into rats with an experimental myocardial infarct and the number of DNA-synthesizing nuclei was determined in various parts of the heart. Myocardial infarction activated DNA synthesis to some extent in the nuclei of monocytes lying at the periphery of the focus of injury. However, there was no doubt about the extremely low density of labeling in the muscle nucleus. Increasing the dose and giving three injections of thymidine-3H did not increase the number of labeled muscle cell nuclei. Activation of proliferation of the connective tissue cells was observed in all parts of the heart. The number of connective-tissue nuclei synthesizing DNA was increased after 24 h, reached a maximum on the second day, and remained above the control level until the end of the experiment.

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Authors
  1. V. R. Babaev
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Babaev, V.R. Autoradiographic study of DNA synthesis in rats with experimental myocardial infarction. Bull Exp Biol Med 83, 726–729 (1977). https://doi.org/10.1007/BF00800763

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  • DOI: https://doi.org/10.1007/BF00800763

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