Abstract
Diethyl- and dimethylnitrosamines, dissolved in aquarium water in doses of 200–400 ppm, induced the formation of neoplasms of the digestive gland (basophil-cell tumors) in the molluskUnio pictorum in 16 of 95 and 6 of 17 animals, respectively, which survived until the time of appearance of the first tumor (38–39 days), and also neoplasms of the hematopoietic system (lymphatic leukemia) in seven and one mollusks, respectively, mainly in conjunction with tumors of the digestive gland. Metylnitronitrosoguanidine caused only inflammatory changes at the site of the injection. The mollusks can be used with advantage as a biological indicator of pollution of the hydrosphere with chemical carcinogens.
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Khudolei, V.V., Sirenko, O.A. Tumor development in the Bivalve mollusk Unio pictorum induced by N-nitroso compounds. Bull Exp Biol Med 83, 684–686 (1977). https://doi.org/10.1007/BF00800749
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DOI: https://doi.org/10.1007/BF00800749