Abstract
A single dose of hydrocortisone (10 mg/100 g body weight) leads to an initial increase, followed by a significant decrease, in the peripheral blood plasma glucocorticoid concentration in rats. Elevation of the glucocorticoid level is accompanied by a decrease in the number of DNA-synthesizing epithelial cells in the urinary bladder, leading to a subsequent decrease in the number of mitoses, whereas a fall in the level of the hormone leads to an increase in the number of cells changing from the G1 into the S period. Meanwhile inhibition of proliferative processes in the epithelium of the kidney continues throughout the experiment (48 h). The possible causes of the unequal sensitivity of epithelial tissues to hydrocortisone are discussed.
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Dyban, P.A., Sapronov, N.S. Action of hydrocortisone on DNA synthesis in the epithelial cells of the urinary bladder and renal cortex and on the blood glucocorticoid level. Bull Exp Biol Med 83, 673–675 (1977). https://doi.org/10.1007/BF00800746
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DOI: https://doi.org/10.1007/BF00800746