Role of the adenylate cyclase system in inductive acetylcholinesterase synthesis in the brain

  • N. G. Aleksidze
  • M. V. Balavadze
Biochemistry and Biophysics


The increase in acetylcholinesterase (ACE) activity in the rat brain after intraventricular injection of adrenalin and the dibutyryl analog of cyclic AMP was shown to be the result of inductive synthesis of the enzyme. Induction of ACE is manifested to a greater degree in the white matter of the subcortex than in the cortex. Blocking β-adrenergic receptors inhibits the stimulating action of adrenalin on ACE activity but does not alter the effect of cyclic AMP. Blocking of the α-adrenergic receptors, on the other hand, potentiates induction of synthesis of the enzyme. The effects of adrenalin and of dibutyryl-cyclic AMP are similar in direction and are mediated through β-adrenergic receptors. The increase in ACE activity after blocking of α receptors can be explained by the elimination of their inhibitory effect on β-adrenergic receptors.

Key Words

acetylcholinesterase rat brain α-and β-adrenergic receptors cyclic nucleotides induction of enzyme synthesis 


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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • N. G. Aleksidze
  • M. V. Balavadze

There are no affiliations available

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