Role of the adenylate cyclase system in inductive acetylcholinesterase synthesis in the brain

  • N. G. Aleksidze
  • M. V. Balavadze
Biochemistry and Biophysics
  • 9 Downloads

Abstract

The increase in acetylcholinesterase (ACE) activity in the rat brain after intraventricular injection of adrenalin and the dibutyryl analog of cyclic AMP was shown to be the result of inductive synthesis of the enzyme. Induction of ACE is manifested to a greater degree in the white matter of the subcortex than in the cortex. Blocking β-adrenergic receptors inhibits the stimulating action of adrenalin on ACE activity but does not alter the effect of cyclic AMP. Blocking of the α-adrenergic receptors, on the other hand, potentiates induction of synthesis of the enzyme. The effects of adrenalin and of dibutyryl-cyclic AMP are similar in direction and are mediated through β-adrenergic receptors. The increase in ACE activity after blocking of α receptors can be explained by the elimination of their inhibitory effect on β-adrenergic receptors.

Key Words

acetylcholinesterase rat brain α-and β-adrenergic receptors cyclic nucleotides induction of enzyme synthesis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    N. G. Aleksidze and M. V. Balavadze, Soobshch. Akad. Nauk Gruz. SSR,81, 189 (1976).Google Scholar
  2. 2.
    É. S. Gevorkyan and G. A. Panosyan, Zh. Éksp. Klin. Med., No. 1, 49 (1974).Google Scholar
  3. 3.
    Ya. I. Zaidler and A. N. Kudrin, Kardiologiya, No. 5, 150 (1975).Google Scholar
  4. 4.
    M. N. Maslova and L. V. Reznik, Dokl. Akad. Nauk SSSR,197, 494 (1971).Google Scholar
  5. 5.
    I. K. Sibul', in: Problems in Neurosurgery [in Russian], Moscow-Leningrad (1966), p. 192.Google Scholar
  6. 6.
    B. McL. Breckenridge and R. E. Johnston, J. Histochem. Cytochem.,17, 505 (1969).Google Scholar
  7. 7.
    G. L. Ellman et al., Biochem. Pharmacol.,7, 88 (1961).Google Scholar
  8. 8.
    W. Feldberg and H. Schriever, J. Physiol. (London),86, 277 (1938).Google Scholar
  9. 9.
    A. J. Mandell, in: Biochemistry of Brain and Behavior (ed by. R. E. Bowman and S. P. Datta), Plenum Press, New York (1970), p. 97.Google Scholar
  10. 10.
    G. Mozsik et al., in: Physiology and Pharmacology of Cyclic AMP, Milan (1974).Google Scholar
  11. 11.
    F. Murad et al., J. Biol. Chem.,237, 1233 (1962).Google Scholar
  12. 12.
    L. Triner et al., in: Physiology and Pharmacology of Cyclic AMP, Milan (1974), p. 54.Google Scholar

Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • N. G. Aleksidze
  • M. V. Balavadze

There are no affiliations available

Personalised recommendations