Action of sodium aurothiomalate in acute toxic hepatitis
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The effect of the lysosomotropic compound sodium aurothiomalate on the character of the liver damage and changes in the lysosomes in acute toxic hepatitis was studied. After the combined action of this compound and CCl4 the extent of spread of necrosis was reduced and the area of zones with degenerative changes in the parenchymatous cells of the liver was increased. The degree of solubilization of acid RNase was reduced. Nonsedimented β-galactosidase and cathepsin D activity was the same as in CCl4 hepatitis.
Key Wordsrat liver lysosomes toxic hepatitis lysosomotropic substances
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