Abstract
Experiments on the human and guinea pig uterus showed that the activity of steroid-receptor interaction of estriol in vitro is 9.4% for the guinea pig and 17% for the human uterus relative to the activity of estradiol. Injection of estriol into guinea pigs in vivo in a dose of 0.25–5 mg sharply reduced the estriol-binding capacity of the uterine receptor system. The existence of competition between estradiol and estriol for binding with the active centers of the receptor proteins of the uterus is postulated.
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Laboratory of Endocrinology All-Union Research Institute of Obstetrics and Gynecology, Ministry of Health of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 79, No. 5, pp. 93–96, May, 1975.
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Persianinov, L.S., Struchak, S.V., Bobrova, E.G. et al. The biological role of estriol. Bull Exp Biol Med 79, 567–570 (1975). https://doi.org/10.1007/BF00800505
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DOI: https://doi.org/10.1007/BF00800505