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Stimulation of cellular immunity and immunologic memory by somatotropic hormone

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The role of somatotropic hormone (STH) in the development of hypersensitivity of delayed type (HDT) and immunologic memory was demonstrated in guinea pigs. Injection of human STH (in doses of 0.25 and 1 mg per guinea pig) in the period of sensitization and formation of HDT stimulated the development of cutaneous hypersensitivity. Inhibition of endogenous STH by means of antiserum against guinea pig STH protected the animal against the development of hypersensitivity in the period both of sensitization and of reaction. HDT was restored after the action of the antiserum ceased. Experiments with a model of immunologic memory showed that the sensitization period is the most sensitive, whereas the period of preservation of immunologic memory remained resistant.

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Authors
  1. T. G. Shemerovskaya
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  2. I. G. Kovaleva
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Shemerovskaya, T.G., Kovaleva, I.G. Stimulation of cellular immunity and immunologic memory by somatotropic hormone. Bull Exp Biol Med 79, 552–554 (1975). https://doi.org/10.1007/BF00800500

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  • DOI: https://doi.org/10.1007/BF00800500

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