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Antagonism between sodium hydroxybutyrate and some effects of aminohydroxyacetic acid

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In agreement with data in the literature, a protective effect of aminohydroxyacetic acid (AHAA) was observed as an inhibitor of 4-aminobutyrate:2-oxoglutarate-aminotransferase (GABA-T) in convulsions induced in mice by thiosemicarbazide (TSC), a glutamate decarboxylase inhibitor. A similar but somewhat weaker action was exhibited by sodium hydroxybutyrate (NaHB). Meanwhile, combined administration of NaHB with AHAA reduced the intensity of its anticonvulsant effect with respect to TSC and reduced the accumulation of GABA in the brain characteristic of the action of AHAA. Competition between AHAA, NaHB, and GABA as structurally closely similar compounds for GABA-T or the GABA-ergic receptor is postulated.

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Literature Cited

  1. E. L. Avenirova, M. N. Maslova, V. I. Rozengart, et al., Vopr. Med. Khimii, No. 6, 633 (1966).

    Google Scholar 

  2. A. P. Arendaruk, L. A. Serebryakov, and A. P. Skoldinov, Med. Prom. SSSR, No. 5, 6 (1963).

    Google Scholar 

  3. R. U. Ostrovskaya, G. N. Artemenko, and K. S. Raevskii, Farmakol. i Toksikol., No. 2, 137 (1970).

    Google Scholar 

  4. R. U. Ostrovskaya, Byull. Éksperim. Biol. i Med., No. 6, 60 (1973).

    Google Scholar 

  5. I. A. Sytinskii, Gamma-Aminobutyric Acid in the Activity of the Nervous System [in Russian], Leningrad (1972).

  6. I. A. Sytinskii, Zh. Vsesoyuz. Khim. Obshch. im. D. I. Mendeleeva,18, No. 2, 182 (1973).

    Google Scholar 

  7. A. E. Uspenskii, V. P. Listvina, and N. M. Tsybina, Farmakol. i Toksikol., No. 2, 185 (1973).

    Google Scholar 

  8. A. Laborit, The Regulation of Metabolic Processes [Russian translation], Moscow (1970).

  9. C. Baxter and E. Roberts, J. Biol. Chem.,236, 3287 (1961).

    Google Scholar 

  10. F. Verster et al., Acta Neurol. Lat.-Amer.,12, 76 (1966/1967).

    Google Scholar 

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Authors
  1. R. U. Ostrovskaya
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  2. A. M. Zubovskaya
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  3. S. S. Boiko
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Ostrovskaya, R.U., Zubovskaya, A.M. & Boiko, S.S. Antagonism between sodium hydroxybutyrate and some effects of aminohydroxyacetic acid. Bull Exp Biol Med 79, 542–544 (1975). https://doi.org/10.1007/BF00800497

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  • DOI: https://doi.org/10.1007/BF00800497

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