Antagonism between sodium hydroxybutyrate and some effects of aminohydroxyacetic acid
In agreement with data in the literature, a protective effect of aminohydroxyacetic acid (AHAA) was observed as an inhibitor of 4-aminobutyrate:2-oxoglutarate-aminotransferase (GABA-T) in convulsions induced in mice by thiosemicarbazide (TSC), a glutamate decarboxylase inhibitor. A similar but somewhat weaker action was exhibited by sodium hydroxybutyrate (NaHB). Meanwhile, combined administration of NaHB with AHAA reduced the intensity of its anticonvulsant effect with respect to TSC and reduced the accumulation of GABA in the brain characteristic of the action of AHAA. Competition between AHAA, NaHB, and GABA as structurally closely similar compounds for GABA-T or the GABA-ergic receptor is postulated.
Key WordsGABA aminohydroxyacetic acid sodium hydroxybutyrate convulsive states
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