Abstract
Aggressiveness arising in rats confronted with an unavoidable nociceptive stimulus is the result of overexcitation of the animals and can be used to detect the sedative effect of psychotropic drugs. A method of evoking motivated fighting in rats for their territory which is suitable for use for determination of the tranquilizing effect of psychotropic drugs is described. It was shown by means of this method that trifluoperazine, haloperidol, amitryptiline, imipramine, chloridazepoxide, diazepam, and benactyzine, in small doses, have a tranquilizing action whereas pentobarbital and chlorpromazine have a mainly sedative action.
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Burov, Y.V., Salimov, R.M. Effect of pharmacological agents on intraspecies aggression. Bull Exp Biol Med 79, 539–541 (1975). https://doi.org/10.1007/BF00800496
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DOI: https://doi.org/10.1007/BF00800496