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Effect of functional strain of the CNS and endocrine disturbances on development of experimental atherosclerosis in dogs

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Functional strain on the CNS was combined in chronic experiments on seven dogs with other factors changing the hormonal status of the animal-castration and injection of mercazolyl in doses of 1.5–2.5 mg/kg (group 1). The six control dogs (group 2) underwent castration and injection of mercazolyl only. The animals of group 1 developed persistent hypercholesteremia, atherosclerotic changes in various intramural arteries, especially of the myocardium, and also degenerative changes in the parenchyma of certain organs, which were not found in the animals of group 2. The results of this investigation demonstrate the important role of functional strain on the CNS as a leading “risk” factor responsible for disturbances of the regulation of lipid metabolism and the development of atherosclerotic changes in the vessels.

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Authors
  1. A. S. Fokin
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  2. N. T. Shutova
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  3. L. N. Lebedeva
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  4. E. D. Klimenko
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Additional information

1-methyl-2-mercaptoimidazole.

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Fokin, A.S., Shutova, N.T., Lebedeva, L.N. et al. Effect of functional strain of the CNS and endocrine disturbances on development of experimental atherosclerosis in dogs. Bull Exp Biol Med 79, 501–504 (1975). https://doi.org/10.1007/BF00800484

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  • DOI: https://doi.org/10.1007/BF00800484

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