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Effect of some extremal factors on the submicroscopic organization of the liver in rats poisoned with carbon tetrachloride

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The submicroscopic study of the parenchymatous cells of the liver of rats receiving carbon tetrachlorde (CCl4) in a dose of 0.12 ml/g body weight repeatedly over a period of 25 days was studied. After the end of poisoning the animals were exposed to various extremal stimuli, namely immobilization, sunburn, or a combination of the two. Administration of CCl4, caused the appearance of many lipid inclusions in the cytoplasm of the hepatocytes, the basis for fatty infiltration of the liver. Under the influence of extremal factors, accumulation of lipid material not found and not previously described in any other pathological condition, and evidently reflecting profound disturbances of intracellular metabolism, was discovered in the spaces of the rough cytoplasmic reticulum.

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Authors
  1. S. L. Gokhberg
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  2. N. I. Rasulev
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  3. N. A. Arslanova
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Gokhberg, S.L., Rasulev, N.I. & Arslanova, N.A. Effect of some extremal factors on the submicroscopic organization of the liver in rats poisoned with carbon tetrachloride. Bull Exp Biol Med 86, 1402–1405 (1978). https://doi.org/10.1007/BF00800472

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  • DOI: https://doi.org/10.1007/BF00800472

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