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Inhibition of noncytotoxic histamine liberation from isolated mast cells by antihistamines in rats

  • Allergology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Phenothiazine (chloropromazine and promethazine) and antihistamine quinuclidine derivatives [Phencarol, quinuclidyl-d-di-(o-tolyl) carbinol, quinuclidyl-3-di-(o-methoxyphenyl) carbinol hydrochloride (QMCH)], in doses below those liberating histamine, inhibited histamine liberation from the mast cells of rats induced by compound 48/80. QMCH inhibited histamine liberation induced by selective liberators (compound 48/80, MCD-peptide, and specific antigen), but potentiated histamine liberation induced by nonselective liberators (Triton X-100 and chlorpromazine). The inhibitory action of QMCH on histamine liberation induced by compound 48/80 increased for 1 min and was reversible. The inhibitory effect of all the compounds tested was reduced to some extent in the presence of glucose.

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Authors
  1. I. S. Gushchin
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  2. M. E. Kaminka
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  3. I. L. Deryugin
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Gushchin, I.S., Kaminka, M.E. & Deryugin, I.L. Inhibition of noncytotoxic histamine liberation from isolated mast cells by antihistamines in rats. Bull Exp Biol Med 86, 1367–1370 (1978). https://doi.org/10.1007/BF00800461

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  • DOI: https://doi.org/10.1007/BF00800461

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