Skip to main content
SpringerLink
Log in

Oxidation-reduction processes during sensitization and the allergic reaction to microbial antigens

  • Allergology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of sensitization and an allergic reaction of delayed type (ARDT) to brucellosis antigen on the state of glycolysis and activity of the dehydrogenases of the Krebs' cycle was studied. Sensitization to brucellas was shown to be accompanied by inhibition of dehydrogenase activity and activation of glycolysis. The changes were more marked in the case of sensitization with living brucellas. In ARDT, besides depression of dehydrogenase activity, glycolysis also was inhibited. In the lactate dehydrogenase isozyme spectrum the content of aerobic fractions and of excess lactate fell both in sensitized animals and in animals with ARDT. Correction of the biochemical disturbances detected in ARDT led to a decrease in the degree of sensitization and to abolition of the ARDT symptom-complex.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. A. D. Ado, General Allergology [in Russian], Moscow (1970).

  2. N. D. Beklemishev, Infectous Allergy [in Russian], Alma-Ata (1968).

  3. Yu. M. Nemenova, Methods of Clinical Laboratory Investigation [in Russian], Moscow (1967).

  4. V. P. Perfilov, Vrach. Delo, No. 5, 47 (1967).

    Google Scholar 

  5. A. A. Pokrovskii, Biochemical Methods of Investigation in Clinical Practice [in Russian], Moscow (1969).

  6. A. A. Pokrovskii and K. A. Korovnikov, Biokhimiya, No. 1 159 (1970).

    Google Scholar 

  7. M. I. Prokhorova and Z. N. Tupikova, Large Textbook of Practical Carbohydrate and Lipid Metabolism [in Russian], Moscow (1965).

  8. W. F. Blatt, J. Walker, and M. Mager, Am. J. Physiol.,209, 785 (1965).

    Google Scholar 

  9. B. I. Davis, Ann. New York Acad. Sci.,121, 404 (1964).

    Google Scholar 

  10. E. Kun and L. G. Abood, Science,109, 144 (1949).

    Google Scholar 

  11. T. Oda and H. Okazaki, Acta Med. Okayama,12, 193 (1958).

    Google Scholar 

  12. L. Ornstein, Ann. New York Acad. Sci.,121, 321 (1964).

    Google Scholar 

  13. M. Sevella and I. Tovarek, Cas. Lek. Cesk.,98, 844 (1959).

    Google Scholar 

  14. J. W. Uhr, Physiol. Rev.,46, 360 (1966).

    Google Scholar 

Download references

Authors
  1. S. M. Pleshkova
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pleshkova, S.M. Oxidation-reduction processes during sensitization and the allergic reaction to microbial antigens. Bull Exp Biol Med 86, 1363–1366 (1978). https://doi.org/10.1007/BF00800460

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00800460

Key Words

Search

Navigation