Abstract
The effect of ecgonine, tropine, tropinone and some of their derivatives, tropane, N-methylpyrrolidine, and N-methylpiperidine on impulse summation in the CNS, the conditioned avoidance reflex, antagonism with hexobarbital, synergism with cocaine, and also their toxicity (LD50) were investigated experimentally. Benzoylecgonine, the methyl ester of ecgonine, ecgonine itself, tropine, pseudotropine, carbomethoxytropinone, tropinone, tropane, N-methylpyrrolidine, and N-methylpiperidine were shown to have a definite stimulating effect on the activity of the CNS and, in this respect, are similar to cocaine. It is concluded that compounds whose molecules contain the structure of tropane or one of its fragments have a central stimulant effect and that the stimulant action of cocaine on the CNS may be associated with the tropane moiety of its molecule.
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Literature Cited
E. Poulsson, in: Handbuch der Experimentallen Pharmakologie (edited by A. Heffter), Vol. 2, Berlin (1920), p. 103.
V. V. Zakusov, Farmakol. Toksikol.,37, 389 (1974).
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Institute of Pharmacology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 10, pp. 435–438, October, 1978.
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Zakusov, V.V., Kostochka, L.M. & Skoldinov, A.P. Action of fragments of the cocaine molecule on the CNS. Bull Exp Biol Med 86, 1325–1327 (1978). https://doi.org/10.1007/BF00800448
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DOI: https://doi.org/10.1007/BF00800448