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Bulletin of Experimental Biology and Medicine

, Volume 86, Issue 4, pp 1290–1293 | Cite as

Changes in the nicotinamide nucleotide content in the brain and myocardium of rats exposed to factors inducing neurogenic dystrophies

  • E. A. Migas
Pathological Physiology and General Pathology

Abstract

The content of nicotinamide nucleotides in the brain and myocardium of rats was investigated during electrical stimulation of the animals and administration of toxic doses of noradrenalin. The level of total nicotinamide nucleotides and their oxidized forms was reduced but the content and rate of synthesis of nicotinamide nucleotide-phosphates were increased. The results point to a disturbance of oxidation-reduction processes and to an increase in the activity of the pentose pathway of carbohydrate utilization in the tissues in neurogenic dystrophies caused by extremal stimulation.

Key Words

neurogenic dystrophies nicotinamide nucleotides energy metabolism brain heart 

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Literature Cited

  1. 1.
    S. V. Anichkov, I. S. Zavodskaya, E. V. Moreva, et al., Neurogenic Dystrophies and Their Pharmacotherapy [in Russian], Leningrad (1969).Google Scholar
  2. 2.
    I. F. Belyaeva, I. D. Pevzner, and V. I. Telepneva, Zh. Évol. Biokhim. Fiziol.,8, 375 (1972).Google Scholar
  3. 3.
    O. N. Zabrodin, in: Annual Report of the Institute of Experimental Medicine, Academy of Medical Sciences of the USSR [in Russian], Vol. 7–8, Leningrad (1963), pp. 212–214.Google Scholar
  4. 4.
    I. S. Zavodskaya, E. V. Moreva, N. A. Novikova et al., Byull. Éksp. Biol. Med., No. 4, 61 (1974).Google Scholar
  5. 5.
    I. S. Zavodskaya, E. V. Moreva, N. I. Zaskal'ko, et al., Farmakol. Toksikol., No. 1, 44 (1975).Google Scholar
  6. 6.
    V. S. Il'in, A. M. Emel'yantseva, V. M. Pleskov, et al., Pat. Fiziol., No. 3, 3 (1972).Google Scholar
  7. 7.
    N. A. Novikova, Byull. Éksp. Biol. Med., No. 10, 1205 (1976).Google Scholar
  8. 8.
    V. I. Telepneva and R. Meshter, Biokhimiya,34, 160 (1969).Google Scholar
  9. 9.
    S. V. Anichkov, I. S. Zavodskaya, and E. V. Moreva, Pharmacology,5, 165 (1971).Google Scholar
  10. 10.
    S. Imai, T. Otorii, K. Takeda, et al., Jpn. J. Pharmacol.,26, 512 (1976).Google Scholar
  11. 11.
    J. Ribeilima, V. E. Wendt, H. Ramos, et al., Am. Heart J.,67, 672 (1964).Google Scholar
  12. 12.
    T. Slater, B. Sawyer, and U. Sträuli, Arch. Int. Physiol. Biochem.,72, 427 (1964).Google Scholar
  13. 13.
    T. Wang and N. Kaplaw, J. Biol. Chem.,206, 311 (1954).Google Scholar
  14. 14.
    J. Williamson and D. Jamieson, Molec. Pharmacol.,2, 191 (1966).Google Scholar

Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • E. A. Migas

There are no affiliations available

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