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Effect of antidiuretic hormone on the ultrastructure of the kidney

  • Morphology and Pathomorphology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

During the antidiuretic reaction induced in rats by injection of antidiuretic hormone after moderate water loading, by contrast with injection of the hormone without water loading, widening of the intercellular spaces and basal labyrinth in the epithelium of the collecting tubules and of the thin descending segment of the loop of the nephron, evidently connected with the presence of an intratubular pressure gradient under these conditions, was found. After injection of the hormone in both variants, vacuolation of the cytoplasm and widening of the perinuclear space of the interstitial cells of the renal medulla took place. The results confirm the hypothesis that intercellular contact plays a role in the transepithelial reabsorption of water in the kidney during the urine concentration process, and they also point to participation of the interstitial cells in this process.

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Literature Cited

  1. A. G. Ginetzinsky (A. G. Ginetsinskii), Nature,182, 1218 (1958).

    Google Scholar 

  2. Yu. V. Natochin and K. Chapek, Methods of Investigation of Ion and Water Transport [in Russian], Leningrad (1976).

  3. Yu. V. Natochin (Y. V. Natochin) and E. I. Shakhmatova, Endocr. Exp.,2, 151 (1968).

    Google Scholar 

  4. R. W. Berliner, Kidney Int.,9, 214 (1976).

    Google Scholar 

  5. R. E. Bulger, L. D. Griffith, and B. F. Trump, Science,151, 83 (1966).

    Google Scholar 

  6. J. Diezi, P. Micoud, J. Aceves, et al., Am. J. Physiol.,224, 623 (1973).

    Google Scholar 

  7. C. E. Ganote, J. J. Grantham, H. L. Moses, et al., J. Cell Biol.,36, 355 (1968).

    Google Scholar 

  8. J. J. Grantham, C. E. Ganote, M. B. Burg, et al., J. Cell Biol.,41, 562 (1969).

    Google Scholar 

  9. M. Imai and J. P. Kokko, J. Clin. Invest.,53, 393 (1974).

    Google Scholar 

  10. J. P. Kokko and C. C. Tisher, Kidney Int.,10, 64 (1976).

    Google Scholar 

  11. H. Levintin, A. Goodman, G. Pigeon, et al., J. Clin. Invest.,41, 1145 (1962).

    Google Scholar 

  12. T. Morgan and R. W. Berliner, Am. J. Physiol.,215, 108 (1968).

    Google Scholar 

  13. L. Osvaldo and H. Latta, J. Ultrastruct. Res.,15, 144 (1966).

    Google Scholar 

  14. G. Siebert, in: The Cell Nucleus (Proceedings of an International Symposium on the Structure and Function of the Cell Nucleus) [in Russian], Moscow (1972, p. 219.

  15. C. C. Tisher, R. E. Bulger, and H. Valtin, Am. J. Physiol.,220, 87 (1971).

    Google Scholar 

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Authors
  1. V. S. Orlov
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Orlov, V.S. Effect of antidiuretic hormone on the ultrastructure of the kidney. Bull Exp Biol Med 86, 1537–1540 (1978). https://doi.org/10.1007/BF00800307

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  • DOI: https://doi.org/10.1007/BF00800307

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