Submicroscopic changes in the thyroid gland in burns
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The submicroscopic changes in the thyrocytes and perifollicular blood capillaries were studied on the 1st, 2nd, 7th, 14th, 21st, and 28th days after experimental burns on sexually mature male guinea pigs. During the period of burn shock the picture in the thyroid gland was dominated by macrofollicles formed by thickened thyrocytes. The lumen of the capillaries was dilated and the ultrastructure of their wall disturbed. On the 7th–14th day an increase in the height of the cells, with hypertrophy and hyperplasia of the intracellular organelles, were observed. Together with hyperplastic changes in the thyrocytes and endothelial cells, destruction of the membranous components of the cells increased; in the later stages of burns (21st and 28th days) this led to the development of severe necrobiotic lesions of the cells and to a sharp disturbance of vaso-parenchymatous relationships in the gland.
Key Wordsthyroid gland ultrastructure burns
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