Bulletin of Experimental Biology and Medicine

, Volume 86, Issue 5, pp 1483–1487 | Cite as

Effect of blood serum fractions from cancer patients on leukocyte migration from capillary tubes

  • L. K. Novikov
  • A. P. Shmakov
  • I. D. Borisenko


In more than half of the cases studied the blood serum from patients with carcinoma of the stomach and urinary bladder inhibited migrationin vitro of autologous leukocytes, leukocytes from blood donors and control patients, and also guinea pig macrophages. Chromatography of these sera on Sephadex G-100 showed that activity inhibiting leukocyte migration was present in fraction I (mol. wt. over 100,000 daltons) and in fractions IV and V (mol. wt. under 30,000 daltons). The blood serum of cancer patients and its fractions did not abolish inhibition of leukocyte migration induced by tumor antigens, by contrast with leukocyte migration in medium with control serum without antigens. It is suggested that activity of fraction I inhibiting leukocyte migration is due to an antigen-antibody complex, whereas in IV and V it is due to a factor similar in its properties to the factor secretein vitro by lymphocytes stimulated by antigens or mitogens.

Key Words

carcinoma of the stomach carcinoma of the urinary bladder blood serum factor inhibiting leukocyte migration in vitro 


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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • L. K. Novikov
  • A. P. Shmakov
  • I. D. Borisenko

There are no affiliations available

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