Bulletin of Experimental Biology and Medicine

, Volume 86, Issue 5, pp 1483–1487 | Cite as

Effect of blood serum fractions from cancer patients on leukocyte migration from capillary tubes

  • L. K. Novikov
  • A. P. Shmakov
  • I. D. Borisenko
Oncology
  • 14 Downloads

Abstract

In more than half of the cases studied the blood serum from patients with carcinoma of the stomach and urinary bladder inhibited migrationin vitro of autologous leukocytes, leukocytes from blood donors and control patients, and also guinea pig macrophages. Chromatography of these sera on Sephadex G-100 showed that activity inhibiting leukocyte migration was present in fraction I (mol. wt. over 100,000 daltons) and in fractions IV and V (mol. wt. under 30,000 daltons). The blood serum of cancer patients and its fractions did not abolish inhibition of leukocyte migration induced by tumor antigens, by contrast with leukocyte migration in medium with control serum without antigens. It is suggested that activity of fraction I inhibiting leukocyte migration is due to an antigen-antibody complex, whereas in IV and V it is due to a factor similar in its properties to the factor secretein vitro by lymphocytes stimulated by antigens or mitogens.

Key Words

carcinoma of the stomach carcinoma of the urinary bladder blood serum factor inhibiting leukocyte migration in vitro 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    V. I. Govallo, M. P. Grigor'eva, and G. A. Kosmiadi, Vopr. Onkol., No. 11, 18 (1973).Google Scholar
  2. 2.
    A. D. Gorbach, D. K. Novikov, and I. N. Gorbach, Zh. Mikrobiol., No. 4, 106 (1977).Google Scholar
  3. 3.
    A. A. Mikhailova and R. V. Petrov, in: Progress in Science and Technology. Series: General Problems in Pathology [in Russian], Vol. 5, Moscow (1977), pp. 7–34.Google Scholar
  4. 4.
    D. K. Novikov and G. P. Adamenko, Dokl. Akad. Nauk SSSR,207, 715 (1974).Google Scholar
  5. 5.
    D. K. Novikov, G. P. Adamenko, and V. I. Novikova, Byull. Éksp. Biol. Med., No. 6, 707 (1976).Google Scholar
  6. 6.
    D. K. Novikov, G. P. Adamenko, and N. P. Dainyak, Zh. Ushn. Nos. Gorl. Bol., No. 1, 31 (1977).Google Scholar
  7. 7.
    V. I. Novikova and D. K. Novikov, Sov. Med., No. 8, 31 (1975).Google Scholar
  8. 8.
    S. Cohen et al., New Engl. J. Med.,290, 882 (1974).Google Scholar
  9. 9.
    J. Hellström et al., Proc. Nat. Acad. Sci. USA,62, 362 (1969).Google Scholar
  10. 10.
    J. Hellström et al. Int. J. Cancer,11, 280 (1973).Google Scholar
  11. 11.
    S. M. Jagarlamoody, et al., Proc. Nat. Acad. Sci. USA,68, 1346 (1971).Google Scholar
  12. 12.
    P. Khaer, Acta Path. Microbiol. Scand.,382, 294 (1974).Google Scholar
  13. 13.
    P. Kotkes and E. Pick, Clin. Exp. Immunol.,35, 1489 (1975).Google Scholar
  14. 14.
    B. R. Nimberg et al., Cancer Res.,35, 1489 (1975).Google Scholar
  15. 15.
    T. Raskalen and J. Wasseman, Int. Arch. Allergy,42, 790 (1971).Google Scholar
  16. 16.
    R. E. Rocklin, J. Immunol.112, 1461 (1954).Google Scholar

Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • L. K. Novikov
  • A. P. Shmakov
  • I. D. Borisenko

There are no affiliations available

Personalised recommendations