Abstract
TheN-arylthioformimidates4 a-e, which may be obtained byS-alkylation of the thioformanilides3 a-e, react with chloroacetylchloride/triethylamine to yield the (3R,4S/3S,4R)-1-aryl-3-chloro-4-methylthio-2-azetidinones5 a-e and the formanilides6 a-e. Dehalogenation of5 b-e with tri-n-butyltinhydride yield the title compounds7 b-e. Hydrogenolysis of7 b and7 c yields7 f and7 g.
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Wiatschka, A., Ongania, KH. Synthese von 1-Ary1-4-methylthio-2-azetidinonen. Monatsh Chem 113, 593–602 (1982). https://doi.org/10.1007/BF00800266
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DOI: https://doi.org/10.1007/BF00800266