Summary
An inquiry was made into some aspects of antitoxic immunity by using the cellular transplantation method. Guinea pigs and rabbits were used for the experiment. The recipients were irradiated: guinea pigs with 200–525 r, rabbits with 550–800 r. The donors were immunized with the diphtheria toxoid and typhoid formol-vaccine. Cells of the spleen, lymph nodes and bone marrow were transplanted. The following was revealed as a result of the work carried out: the cells of all the tissues used were capable of producing the antibodies in the organism of the irradiated recipient; one and the same organ responds by antibody production to both antigens used: production of both antibodies pursued a parallel course with the maximum on the 6–10th day; on the 15th–20th day they were undetectable. Recipients gave no anammestic reaction to the antigen injection 15 days after the cell transplantation.
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Kaulen, D.R. Antitoxin formation by cells transplanted into an irradiated animal. Bull Exp Biol Med 55, 53–56 (1964). https://doi.org/10.1007/BF00800201
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DOI: https://doi.org/10.1007/BF00800201