Abstract
The number of mitoses and of DNA-synthesizing cells in an Ehrlich's ascites carcinoma was studied during the 24 h after injection of dibutyryl cyclic 3′,5′-adenosine monophosphate. As a result of preprophase inhibition and, probably, of stimulation of entry of the cells into the synthetic period, a large number of cells commences mitosis simultaneously 8 h after the injection. The resulting synchronization of mitosis in the cell population of the tumor is evaluated.
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Volkov, I.N. Synchronizing action of cyclic AMP on the mitotic cycle of ehrlich's ascites carcinoma cells. Bull Exp Biol Med 81, 82–84 (1976). https://doi.org/10.1007/BF00800175
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DOI: https://doi.org/10.1007/BF00800175