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Proliferative activity of the epithelium of the rat large intestine during carcinogenesis

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The labeling index and mitotic index were studied in the epithelium of the descending colon and ileum of rats during induction of intestinal tumors with 1,2-dimethylhydrazine. As early as 1 month after the beginning of the experiments a sharp increase in the number of pathological mitoses (up to 51%) and a change in the ratio between the phases of mitosis, with marked predominance of metaphases (up to 73%) were observed in the epithelium of the descending colon; later these indices were unchanged. Starting from the third month of the experiment an increase in the labeling index (especially in carcinoma in situ) and mitotic index was observed. In the epithelium of the ileum, where tumors never develop, proliferative activity and the mitotic index were unchanged.

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Authors
  1. K. M. Pozharisskii
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Pozharisskii, K.M. Proliferative activity of the epithelium of the rat large intestine during carcinogenesis. Bull Exp Biol Med 81, 76–78 (1976). https://doi.org/10.1007/BF00800173

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  • DOI: https://doi.org/10.1007/BF00800173

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