Abstract
The effect of heparin and heparin-precipitated fraction of human blood plasma (HPF) on the ability of spleen cells of mice immunized with sheep's red blood cells to form plaques in vitro was studied. Heparin and HPF were found to inhibit plaque formation as a result of interaction with lymphocytes. It is postulated that the possible point of application of the action of heparin and HPF may be surface cell membranes of the antibody-forming cells.
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Literature Cited
F. S. Baranova, L. K. Popova, and E. G. Serebryakov, Byull. Éksperim. Biol. Med., No. 6, 58 (1972).
B. D. Brondz and A. E. Snegireva, Tsitologiya, No. 1, 74 (1973).
V. P. Kaznacheev, in: Problems in the Physiology and Pathology of Heparin. Proceedings of a Symposium [in Russian], Novosibirsk (1965), p. 113.
I. E. Kovalev, A. A. Podkolzin, and I. D. Ionov, in: Transplantation of Organs and Tissues [in Russian], Riga (1972), p. 199.
E. M. Petrova, “The heparin-precipitated fraction in the diagnosis of activity of the rheumatic process,” Author's Abstract of Candidate's Dissertation, Novosibirsk (1971).
S. P. Shurin, in: Problems in the Physiology and Pathology of Heparin. Proceedings of a Symposium [in Russian], Novosibirsk (1965), p. 13.
A. J. Cunningham, Nature,207, 1106 (1965).
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Kaznacheev, S.V., Kozlov, V.A., Petrova, E.M. et al. Action of heparin and heparin-precipitated fraction of human blood plasma on antibody-producing cells in vitro. Bull Exp Biol Med 81, 70–72 (1976). https://doi.org/10.1007/BF00800171
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DOI: https://doi.org/10.1007/BF00800171