Abstract
When actinomycin D was used as an immunodepressant in a dose of 2.5 mg/kg, interferon formation was reduced by 16 times compared with the control and antibody production was completely suppressed. Hydrocortisone, in a dose of 100 mg/kg body weight, also reduced interferon production by 16 times, but antibody formation against Newcastle disease virus was undisturbed. Hydrocortisone affects the formation of antiviral immunity in a similar way to antilymphocytic serum, whereas the action of actinomycin D can be compared with that of x-ray irradiation and imuran, suggesting heterogeneity of the population of interferon-producing cells in the body.
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Solov'ev, V.D., Sorokin, A.M. Comparative effect of actinomycin D, imuran, and hydrocortisone on interferon and antibody formation in mice. Bull Exp Biol Med 81, 65–66 (1976). https://doi.org/10.1007/BF00800169
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DOI: https://doi.org/10.1007/BF00800169