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Serotonin uptake by human platelets as a method of screening antidepressants

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Antidepressants of the imipramine group considerably inhibit serotonin uptake by human platelets in concentrations of 10−7 to 10−5 M. Of the neuroleptics, only haloperidol (10−5 M) significantly inhibits serotonin uptake by platelets. Amphetamine and cholinolytics do not affect serotonin uptake by platelets even in a concentration of 10−4 M. The specificity of the effect of the antidepressants confirms the view that their thymoanaleptic action is an indirect effect brought about through activation of serotoninergic processes.

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Authors
  1. G. F. Oksenkrug
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Oksenkrug, G.F. Serotonin uptake by human platelets as a method of screening antidepressants. Bull Exp Biol Med 81, 63–64 (1976). https://doi.org/10.1007/BF00800168

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  • DOI: https://doi.org/10.1007/BF00800168

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