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Effects of neurotropic drugs on hypothalamic self-stimulation

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Amphetamine, cocaine, caffeine, morphine, and imipramine were shown to lower the threshold of the self-stimulation response at the hypothalamic level. Meprobamate, diazepam, and chlordiazepoxide have no effect on the threshold of self-stimulation but increase the number of self-stimulations in response to threshold, optimal, and above-optimal strengths of current. Benactyzine, DLK-25, and phenobarbital lower the threshold of self-stimulation and increase the number of self-stimulations to currents of all parameters. It is concluded that the drugs of the first group have a direct activating action on the system of positive emotions. Tranquilizers activate this system indirectly, through their depriming action on the system of negative emotions. Benactyzine, DLK-25, and phenobarbital activate the system of positive emotions and depress the system of negative emotions.

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Authors
  1. Yu. V. Burov
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  2. S. A. Borisenko
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Burov, Y.V., Borisenko, S.A. Effects of neurotropic drugs on hypothalamic self-stimulation. Bull Exp Biol Med 81, 51–54 (1976). https://doi.org/10.1007/BF00800164

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  • DOI: https://doi.org/10.1007/BF00800164

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