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Succinate dehydrogenase activity of isolated myocardial mitochondria in chronic heart failure

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Succinate dehydrogenase (SD) activity of mitochondria isolated from the muscle cells of the chronically failing heart was studied. Highest SD activity was found in mitochondria of condensed type. Low enzyme activity was observed in orthodox mitochondria. SD activity in mitochondria of intermediate type was midway between activity of the enzyme in orthodox and condensed mitochondria. Orthodox and intermediate forms of mitochondria were predominant in the fraction tested, reflecting lowered SD activity in the heart muscle tissue. Biochemical investigation of the mitochondrial fraction revealed a state of mild uncoupling of respiration and oxidative phosphorylation. The observed decrease in SD activity evidently characterizes a state of overstrain of the energy-producing structures.

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Authors
  1. N. N. Kleimenova
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  2. O. E. Kolesova
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  3. Yu. S. Chechulin
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Kleimenova, N.N., Kolesova, O.E. & Chechulin, Y.S. Succinate dehydrogenase activity of isolated myocardial mitochondria in chronic heart failure. Bull Exp Biol Med 81, 45–48 (1976). https://doi.org/10.1007/BF00800162

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  • DOI: https://doi.org/10.1007/BF00800162

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